A perennial six-month COVID vaccine "booster" treadmill is not the solution, but the problem since it perpetuates a vaccinated host population for natural selection of new variants due to immune pressure.
This is the same phenomenon with influenza vaccine.
I see no resolution of this pandemic in sight granted the present vaccine and drug strategies. Until you block oro-nasal transmission, spread shall persist and masking will be required.
Until you block viral-host interaction, infection and intracellular viral reproduction will persist.
Current monovalent vaccines and boosters will perpetuate the natural selection of new SARS variants.
Joseph N. Manago